Emerging therapies continue to enhance our ability to provide three-dimensional hard and soft tissue regenerative therapy for periodontal and implant applications. Applying bone grafting or now tissue engineering to clinical decision-making achieves optimal biological esthetic results for challenging periodontal and implant cases. Cases will be presented to demonstrate simplified approaches to challenging implant cases. Techniques utilizing block, particulate grafting, hard tissue ridge augmentation and soft tissue grafting for periodontal and implant applications will be presented.