Future Horizons in Periodontology: Peri-Implant Disease and Associated Regenerative Alternatives

Monday, Oct. 29
10:45 a.m. - 12:15 p.m.

This session will consist of three speakers highlighting future directions and emerging concepts in periodontics. The speakers are faculty and practitioners who have benefited from American Academy of Periodontology Foundation initiatives. Each speaker will give a 20-minute presentation, followed by a discussion.

Moderators: Praveen Gajendrareddy and Hector F. Rios 
Speakers: 
Fernando Suárez López del Amo - Etiopathogenesis of Peri-Implantitis: Beyond Plaque

Educational Objectives:

• Explain the multifactorial etiology of peri-implantitis recognizing the various local, systemic, and implant- related factors associated with the disease. 
• Recognize the role of titanium particles on the peri-implant cell population. 
• Identify the focus of new investigations aiming at further elucidating the role of titanium particles in the peri-implant environment. 

Sivaraman Prakasam - Alveolar Regeneration – Bench to Clinics

Educational Objectives:
• Discuss efforts to develop a novel tissue-on-chip platform to systematically study alveolar regenerative and osteolytic processes based on how organs-on-a-chip, or “tissue-chips,” integrate micro-engineered substrates with microfluidics technologies with the goal of replicating tissue/organ level functionality. These chips allow deconstructing the tissue/ organ of choice into their distinct essential elements and enable systematic, precise, and tunable testing of each individual element’s contributions to tissue homeostasis.
• Discuss the role of novel innate immune proteins e.g., Peptidoglycan recognition proteins in tissue destruction during osteolytic disease progression. • Explain the clinical use of Amnion Chorion membranes for site preservation and present evidence from a randomized clinical trial. 

Kevin Matthew Byrd – Reservoirs for Regeneration - Diverse Applications of Oral Epithelial Stem/ Progenitor Cells

Educational Objectives:
• Discuss how oral mucosal epithelia (OE) are maintained by an active basal layer throughout life which is increasingly recognized as containing unique populations of stem/ progenitor cells with diverse capabilities for rebuilding soft tissues.
• Recognize that these heterogeneous OE populations are also at the frontline from a polymicrobial challenge and the diverse roles they play in innate immunity, adhesion, regeneration, and epigenetic regulation.
• Grasp how, when combined with emerging technologies such as 3-D printing, single-cell sequencing, and somatic cell genomic editing, isolation of these OE cells provides a unique opportunity 1) to regenerate “enhanced” soft tissues for keratinized autologous grafts and 2) to understand the complexity of these populations during both health and periodontal disease to identify novel and specific targets for future adjuvants to traditional therapy.