The periodontist is critical in managing the treatment of patients with systemic complexities. This course will cover three medical issues which impact treatment decisions: diabetes, bisphosphonates and anticoagulant therapy. In a patient with diabetes, successful periodontal therapy requires glycemic control, while successful medical treatment is facilitated by good oral health. Critical strategies for patient care based on an improved understanding of diabetes and its current medical management will be presented. The second section will update bisphosphonate-related osteonecrosis of the jaw (BRONJ). Anticoagulant therapy may alter treatment planning and interact with other medications. A physician’s view of our role in management of the patient on this type of therapy will be presented.